Alpha-1 Antitrypsin Deficiency and Tobacco Smoking: Exploring Risk Factors and Smoking Cessation in a Registry Population

The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is strongly associated with COPD, even in never-smokers. Moderate AATD genotypes (MZ and SZ) have been shown to increase the severity COPD smokers. In this comparative study, we examine association between AATD, genotypes, smoking cessation. Two hundred ninety-three Irish people [MZ (n = 91), SZ 72), ZZ/rare 130)] completed a custom questionnaire assessing their social histories. primary outcomes analyzed were predictors ever-smoking effect on awareness maintained cessation, using logistic regression analyses. Parental exposure was status (OR 1.84 vs. no parental smoking, p 0.018), higher cumulative tobacco consumption (23.47 14.87 pack-years, 0.005) more quit attempts required achieve cessation among former-smokers (2.97 5.60, 0.007). Awareness 67.7% versus 56.3% 33% for ZZ, SZ, MZ, respectively (p < 0.001). Among ever-smokers, current-smoking uncommon (2.5% 17% 16% respectively, 0.009) ZZs significantly less likely be current-smokers 0.15 relative 0.025). These results suggest that genetic risk families compounded by transmission factors (via smoking). Increasing lower rates ever-smokers. Whether attributable greater an area interest. Achieving change habits may also result positive health behavior subsequent generations.